# Lille Score Calculator (Response to Steroids in Alcoholic Hepatitis)

URL: https://speedycalculator.com/calculators/health/lille-score/
Last updated: 2026-10-30

> The Lille score calculator predicts whether a patient with severe alcoholic hepatitis is responding to corticosteroids after 7 days, from age, albumin, bilirubin at days 0 and 7, kidney function and prothrombin time.

## Inputs

- Age (years)
- Albumin (day 0) (g/dL, g/L)
- Bilirubin day 0 (mg/dL, µmol/L)
- Bilirubin day 7 (mg/dL, µmol/L)
- Creatinine above 1.3 mg/dL
- Prothrombin time (day 0) (s)

## Results

- R
- Lille score

## Formula

```
R = 3.19 − 0.101 × age + 0.147 × albumin (g/L) + 0.0165 × (bili day 0 − bili day 7) (µmol/L) − 0.206 × renal insufficiency − 0.0065 × bili day 0 − 0.0096 × PT (s)
Lille = e^(−R) ÷ (1 + e^(−R))
≥ 0.45: non-response (stop steroids)
```

## Explanation

Patients who do not respond to steroids by day 7 gain no benefit from continuing them and face the risk of infection. A Lille score of 0.45 or more predicts a 6-month survival of about 25%.

### How to use the Lille Score Calculator

- **Age**
- **Albumin (day 0)**
- **Bilirubin day 0**
- **Bilirubin day 7**
- **Creatinine above 1.3 mg/dL**
- **Prothrombin time (day 0)**

Results update as you type, and every field accepts the units shown in its menu.

### How it works

Enter the values at the start of treatment and the bilirubin at day 7. Renal insufficiency means creatinine above 1.3 mg/dL (115 µmol/L).

### Inputs explained

FieldWhat to enterAgeIn yearsAlbumin (day 0)Units: g/dL, g/LBilirubin day 0Units: mg/dL, µmol/LBilirubin day 7Units: mg/dL, µmol/LCreatinine above 1.3 mg/dLChoose one: No, YesProthrombin time (day 0)In s

### Example values

How the main result changes when **Age** changes and everything else stays at the example values above:

Age (years)Lille score250.0137.50.04500.1462.50.36750.671000.96
*Health note: this calculator is for education and screening only and is not a diagnosis or treatment advice. Discuss your results with a qualified clinician.*

## Worked example

Inputs — Age: 50 years; Albumin (day 0): 2.8 g/dL; Bilirubin day 0: 15 mg/dL; Bilirubin day 7: 10 mg/dL; Creatinine above 1.3 mg/dL: No; Prothrombin time (day 0): 18 s.

Results — R = 1.827; **Lille score = 0.14**.

## Key terms

- **Lille model**: Prognostic model for response to steroids in alcoholic hepatitis.

## FAQ

**What is a good Lille score?**
Below 0.45, indicating response to steroids.

**Why is it calculated at day 7?**
Bilirubin change over the first week best predicts response.

**What happens in non-responders?**
Steroids are usually stopped; early transplant may be considered in selected patients.


## Sources

- [Louvet A et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17518367/)