Patients who do not respond to steroids by day 7 gain no benefit from continuing them and face the risk of infection. A Lille score of 0.45 or more predicts a 6-month survival of about 25%.
How to use the Lille Score Calculator
- Age
- Albumin (day 0)
- Bilirubin day 0
- Bilirubin day 7
- Creatinine above 1.3 mg/dL
- Prothrombin time (day 0)
Results update as you type, and every field accepts the units shown in its menu.
How it works
Enter the values at the start of treatment and the bilirubin at day 7. Renal insufficiency means creatinine above 1.3 mg/dL (115 µmol/L).
Inputs explained
| Field | What to enter |
|---|---|
| Age | In years |
| Albumin (day 0) | Units: g/dL, g/L |
| Bilirubin day 0 | Units: mg/dL, µmol/L |
| Bilirubin day 7 | Units: mg/dL, µmol/L |
| Creatinine above 1.3 mg/dL | Choose one: No, Yes |
| Prothrombin time (day 0) | In s |
Example values
How the main result changes when Age changes and everything else stays at the example values above:
| Age (years) | Lille score |
|---|---|
| 25 | 0.01 |
| 37.5 | 0.04 |
| 50 | 0.14 |
| 62.5 | 0.36 |
| 75 | 0.67 |
| 100 | 0.96 |
Health note: this calculator is for education and screening only and is not a diagnosis or treatment advice. Discuss your results with a qualified clinician.
Formula
R = 3.19 − 0.101 × age + 0.147 × albumin (g/L) + 0.0165 × (bili day 0 − bili day 7) (µmol/L) − 0.206 × renal insufficiency − 0.0065 × bili day 0 − 0.0096 × PT (s)
Lille = e^(−R) ÷ (1 + e^(−R))
≥ 0.45: non-response (stop steroids)
Worked example
Inputs — Age: 50 years; Albumin (day 0): 2.8 g/dL; Bilirubin day 0: 15 mg/dL; Bilirubin day 7: 10 mg/dL; Creatinine above 1.3 mg/dL: No; Prothrombin time (day 0): 18 s.
Results — R = 1.827; Lille score = 0.14.
Key terms
- Lille model
- Prognostic model for response to steroids in alcoholic hepatitis.
Frequently asked questions
What is a good Lille score?
Below 0.45, indicating response to steroids.
Why is it calculated at day 7?
Bilirubin change over the first week best predicts response.
What happens in non-responders?
Steroids are usually stopped; early transplant may be considered in selected patients.