Clot-busting drugs restore blood flow in ischaemic stroke when given within 4.5 hours of symptom onset in eligible patients. Accurate weight is essential; doses are always checked by two clinicians.
How to use the tPA Dose Calculator
- Weight
Results update as you type, and every field accepts the units shown in its menu.
How it works
Enter the patient’s weight. Strict eligibility criteria and local protocols apply.
What each result means
- Alteplase total dose = min(0.9×[Weight], 90)
- Alteplase bolus (10%) = [Alteplase total dose]×0.1
- Alteplase infusion over 60 min (90%) = [Alteplase total dose]×0.9
- Infusion rate (1 mg/mL) = [Alteplase infusion over 60 min (90%)]
- Tenecteplase dose = min(0.25×[Weight], 25)
Example values
How the main result changes when Weight changes and everything else stays at the example values above:
| Weight (kg) | Alteplase total dose (mg) |
|---|---|
| 40 | 36 |
| 60 | 54 |
| 80 | 72 |
| 100 | 90 |
| 120 | 90 |
| 160 | 90 |
Health note: this calculator is for education and screening only and is not a diagnosis or treatment advice. Discuss your results with a qualified clinician.
Formula
Alteplase: total = 0.9 mg/kg (max 90 mg); bolus = 10% over 1 min; infusion = 90% over 60 min
Tenecteplase (stroke): 0.25 mg/kg single bolus (max 25 mg)
Worked example
Inputs — Weight: 80 kg.
Results — Alteplase total dose = 72 mg; Alteplase bolus (10%) = 7.2 mg; Alteplase infusion over 60 min (90%) = 64.8 mg; Infusion rate (1 mg/mL) = 64.8 mL/h; Tenecteplase dose = 20 mg.
Key terms
- tPA
- Tissue plasminogen activator.
Frequently asked questions
What is the maximum alteplase dose for stroke?
90 mg.
Why is the stroke dose lower than for heart attacks?
To reduce the risk of brain bleeding.
Is tenecteplase used for stroke?
Yes – guidelines now endorse 0.25 mg/kg as an alternative.