In the mid-luteal phase progesterone is normally 100 to 500 times higher than estradiol. Some practitioners describe a lower ratio as “estrogen dominance”, though the term is not a medical diagnosis. In IVF, a high progesterone-to-estradiol ratio at trigger has been linked with lower pregnancy rates.
How to use the Progesterone to Estradiol Ratio Calculator
- Progesterone
- Estradiol
Results update as you type, and every field accepts the units shown in its menu.
How it works
Enter both hormone levels from a blood test taken about 7 days after ovulation (cycle day 21 in a 28-day cycle).
Inputs explained
| Field | What to enter |
|---|---|
| Progesterone | Units: ng/mL, nmol/L |
| Estradiol | Units: pg/mL, pmol/L, ng/mL |
Example values
How the main result changes when Progesterone changes and everything else stays at the example values above:
| Progesterone (ng/mL) | Progesterone / estradiol ratio |
|---|---|
| 7.5 | 63 |
| 11.25 | 94 |
| 15 | 125 |
| 18.75 | 156 |
| 22.5 | 188 |
| 30 | 250 |
Health note: this calculator is for education and screening only and is not a diagnosis or treatment advice. Discuss your results with a qualified clinician.
Formula
P/E2 = progesterone (pg/mL) ÷ estradiol (pg/mL)
Progesterone: 1 ng/mL = 3.18 nmol/L = 1000 pg/mL
Estradiol: 1 pg/mL = 3.671 pmol/L
Worked example
Inputs — Progesterone: 15 ng/mL; Estradiol: 120 pg/mL.
Results — Progesterone / estradiol ratio = 125.
Key terms
- P/E2
- Progesterone-to-estradiol ratio.
Frequently asked questions
When should P and E2 be tested?
About 7 days after ovulation, in the mid-luteal phase.
What is a normal mid-luteal progesterone?
Typically above 10 ng/mL (32 nmol/L) after ovulation.
Is "estrogen dominance" a diagnosis?
No – it is a descriptive term; symptoms should be assessed by a doctor.